Changes in Serum Fatty Acid Composition and Metabolome-Microbiome Responses of Heigai Pigs Induced by Dietary N-6/n-3 Polyunsaturated Fatty Acid Ratio
Pork is one of the most produced and consumed meats in the world. It is an important source of protein, lipids, and other nutrients in the human diet, which is closely related to human health. However, pork has not reached the best fatty acid composition that is beneficial to human health due to the regular feeding practices ...
Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice
Aging is characterized by the gradual loss of physiological integrity, organs dysfunction, tissue loss of homeostasis and reduced regenerative capacity [1,2]. Aging is associated with the increased of genomic instability, telomere attrition, epigenetic changes, impaired nutrient perception, mitochondrial dysfunction ...
Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma
The posttranscriptional RNA modification known as N6-methyladenosine (m6A) is highly prevalent in mammalian mRNA and has been associated with various physiological and pathological mechanisms [1], [2]. The addition of m6A modification can be achieved by m6A methyltransferases, and its removal is mediated by ...
Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice
Perfluorinated compounds (PFCs) refer to a type of organic compounds in which all the hydrogen atoms linked to carbon atoms in the compound molecules are replaced by fluorine atoms. PFCs mainly include perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHpA), and other compounds ...
Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota
Nonspecific chronic inflammation of the intestines with multiple predisposing factors is termed as inflammatory bowel disease (IBD) which include genetic factors, immune disorders, intestinal barrier dysfunction and altered gut microbiota. Furthermore, environmental factors like altered diet, antibiotic use and smoking also play a ...
Body size as key trait determining aquatic metacommunity assemblies in benthonic and planktonic habitats of Dongting Lake, China
Aquatic biodiversity is complex and diverse with millions of species including bacteria, fungi, protists and invertebrates such as zooplankton and zoobenthos (Holman et al., 2021). These organisms drive the process of material cycling in freshwater ecosystem, and maintain ecological functions such as carbon, nitrogen, phosphorus and ...
Development of potent antibody drug conjugates against ICAM1+ cancer cells in preclinical models of cholangiocarcinoma
Cholangiocarcinoma (CCA) is a highly lethal malignancy that occurs at various locations in the biliary tree1. It is the second most common primary liver malignancy after hepatocellular carcinoma, accounting for 15% of primary liver cancers, and the overall incidence is on the rise globally2,3. Cancers originating in ...
Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria
Cancer metastasis is an important factor leading to the death of patients.1 However, despite the use of neoadjuvant chemotherapy, the long-term survival rates of osteosarcoma patients are not satisfactory due to the high incidence of lung metastasis.2,3 Metastasizing cells regulate oxidative stress via ...
ALKBH5 promotes hypopharyngeal squamous cell carcinoma apoptosis by targeting TLR2 in a YTHDF1/IGF2BP2-mediated manner
Hypopharyngeal squamous cell carcinoma (HPSCC) is an extremely aggressive malignancy that, in 60% of cases, is detected at an advanced stage, contributing to the generally poor prognosis and the low 5-year overall survival (OS) rate [1,2,3,4,5]. Furthermore, these tumors and associated treatments may have a negative...
ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression
Aging is a critical factor affecting human health and is closely related to the occurrence of degenerative diseases, such as osteoarthritis (OA) and osteoporosis (OP)1. Studies have found that cellular senescence is an important cause of organism aging2. Due to multiple replications, oxidative stress or radiation ...
Abnormal DNA methylation analysis of leucine-rich glioma-inactivated 1 antibody encephalitis reveals novel methylation-driven genes related to prognostic and clinical features
Patients with limbic encephalitis (LE) and antibodies against LGI1 antibody are typically older men with severe anterograde amnesia, psychiatric symptoms, and seizures, as well as medial temporal lobe abnormalities on brain MRI, but, bafflingly, frequently without inflammatory signs in cerebrospinal fluid ...
A phylotranscriptomic dataset of angiosperm species under cold stress
Due to their sessile nature, plants have evolved sophisticated signaling pathways in adaptation to complex environmental fluctuations such as extreme temperature, high salinity, and drought1,2. Low temperature is one of the environmental stresses that causes a series of physiological and metabolic changes in plants3,4, and ...
A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance
Liver cancer accounts for the sixth most common type of human cancer and the fourth-leading cause of cancer-related death worldwide1. Liver cancer almost invariably occurs in patients with chronic liver diseases caused by hepatitis B or C virus infection, aflatoxin intake, alcohol abuse, metabolic syndrome, diabetes and ...
Combined exposure to polyvinyl chloride and polystyrene microplastics induces liver injury and perturbs gut microbial and serum metabolic homeostasis in mice
Plastic productions are indispensable in daily life due to their low cost, durability, and processability (Browne et al., 2011). The production and use of plastics have increased sharply. It is estimated that the global quantity of plastic products will reach 33 billion tons by 2050 (Phillips and Bonner, 2015, Prata et al., 2020). In recent years, ...
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease
Inflammatory bowel diseases (IBD) describe chronic, nonspecific inflammatory conditions, including ulcerative colitis (UC) and Crohn's disease (CD). While primarily affecting the digestive system, IBD also impacts various other systems such as the nervous system [1], musculoskeletal system, dermatologic system, and visual system ...