Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality.
miRNA microarray expression profiling conducted by researchers from Brigham and Women’s Hospital on RNA prepared from IRI, sham, and naive kidneys of mice revealed nine miRNAs that are differentially expressed following IRI when compared with sham controls.
The differentially expressed miRNAs could be placed into four groups based on their expression patterns. These findings define a molecular fingerprint of renal injury.
Identification of a miRNA signature following renal IRI.
(A) Heat map of miRNAs differentially expressed in the kidneys of mice after IRI or sham operation. (B) Plots of above microarray data expressed as the mean signal intensity ± SE.
The differentially expressed miRNAs could be placed into four groups based on their expression patterns following IRI: group 1 was rapidly up-regulated, group 2 also up-regulated, group 3 was rapidly down-regulated, group 4 was also down-regulated.
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Reference
Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG, Iacomini J. (2010) Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci USA 107(32), 14339-44. [article]