Lactic acid bacteria naturally associated with ready-to-eat rocket salad can survive the human gastrointestinal transit
The human gut microbiota plays a crucial role in maintaining human health, and its composition can be influenced by various factors such as lifestyle, diet, and medication. Recent studies suggest that with industrialization, we also experienced a drastically reduced harmless microbial population associated with ...
Join LC Sciences at the AACR Annual Meeting – 2024
LC Sciences will be exhibiting at the AACR Conference New Orleans, Louisiana – April 8th to 13th! We are very excited to attend and talk about our services! We invite you to stop by and learn more about our company. We will be located in Booth 1459
K235 acetylation couples with PSPC1 to regulate the m6A demethylation activity of ALKBH5 and tumorigenesis
N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic mRNAs. In mammals, m6A is installed on mRNA by the m6A methyltransferases METTL3 and METTL14 (writers) and erased by the demethylases ALKBH5 and FTO (erasers)1,2,3,4,5. The m6A modification of mRNA plays critical roles in ...
LPS adsorption and inflammation alleviation by polymyxin B-modified liposomes for atherosclerosis treatment
As one of the fundamental pathologic alterations in the majority of cardiovascular diseases, atherosclerosis (AS) is a complex, progressive, and multifaceted illness possessing properties of lipid deposition, inflammatory cell aggregation, and ultimate atheromatous plaques occurring in artery walls, which ...
Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage in Drosophila melanogaster
Inflammatory bowel disease (IBD) is a chronic recurrent disease that is known to cause life-long recurrence of abnormal inflammation in the intestinal tissue. Disruption of the epithelial barrier represents the initiating step of intestinal inflammation. Epithelial cells, which provide structural barrier components from ...
Fecal microbiota and metabolomics revealed the effect of long-term consumption of gallic acid on canine lipid metabolism and gut health
Polyphenolic compounds, ubiquitous in plant-derived foods, are an essential part of the human and animal diet. Recently, plant polyphenols have become increasingly popular worldwide as the consumption of polyphenols can reduce the risk of chronic disease, such as cardiovascular diseases, obesity, type-2 ...
Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy
At present, female breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death [1]. Triple-negative breast cancers (TNBCs), the most aggressive subtype of this disease, are associated with increased risk of developing metastatic disease and reduced survival rates [2, 3]. Despite being a ...
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
Both sporadic and familial forms of Alzheimer’s disease (AD) are associated with the presence of the E4 allele of Apolipoprotein E (APOE) [1, 2]. Indeed, relative to the most prevalent E3 allele representing the ‘reference allele’, the E4 allele significantly increases the risk of AD and lowers the age of dementia onset in a ...
Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis
Antiphospholipid syndrome (APS) is an autoimmune disorder that occurs when circulating antiphospholipid antibodies (aPLs) lead to thrombogenesis and/or pathological pregnancy [1, 2]. APS is referred to as obstetric antiphospholipid syndrome (OAPS) when pathological pregnancy is the main manifestation, such as recurrent ...
Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury
Acute compartment syndrome (ACS) is a severe musculoskeletal injury observed in clinical and characterized by a sudden and sharp increase in osseofascial pressure [1]. Timely reperfusion therapy through fasciotomy is crucial for reducing pressure-induced skeletal muscle injury [2, 3]. However, the reperfusion process can lead ...
Gut microbiota of old mice worsens neurological outcome after brain ischemia via increased valeric acid and IL-17 in the blood
Pork is one of the most produced and consumed meats in the world. It is an important source of protein, lipids, and other nutrients in the human diet, which is closely related to human health. However, pork has not reached the best fatty acid composition that is beneficial to human health due to the regular feeding practices ...
Homodimer-mediated phosphorylation of C/EBPα-p42 S16 modulates acute myeloid leukaemia differentiation through liquid-liquid phase separation
CCAAT/enhancer-binding protein alpha (C/EBPα) is a basic-leucine zipper (bZIP) transcription factor and serves as a main regulator of myeloid differentiation and leukaemogenesis1,2. Two major C/EBPα protein isoforms exist: the 42 kDa full length protein (p42) and the 30 kDa truncated isoform (p30), which lacks ...
Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways
Osteoporosis (OP), which is mainly characterized by low bone mineral density (BMD) and increased susceptibility to low trauma fractures, is most prevalent in post-menopausal women (termed postmenopausal osteoporosis (PMOP)). 4.9 million post-menopausal women in the US suffered osteoporotic fractures between ...
Exosomes secreted by endothelial cells derived from human induced pluripotent stem cells improve recovery from myocardial infarction in mice
Myocardial infarction (MI) causes irreversible cell death and may lead to heart failure (HF). It is the leading cause of morbidity and mortality worldwide [1,2,3,4]. Cell therapy, such as human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs), has emerged as a potential approach to repairing the infarcted heart ...
Engineering cannabidiol synergistic carbon monoxide nanocomplexes to enhance cancer therapy via excessive autophagy
As an endogenousgaseous molecule, CO showed various biological functions including anti-inflammatory1, anti-proliferative2, pro-apoptotic properties3, and so on. Meanwhile, this kind of gas can interfere with cytochrome c oxidase of mitochondrial electron transport chain to accelerate cellular respiration and ATP ...